Active ingredient: Verapamil Hydrochloride

Brand Name: Calan, Verelan PM, Isoptin, Verelan, Calan SR

Drug class: Antihypertensives

Mechanism of Action:

Verapamil is a calcium channel blocker primarily used to treat heart conditions, including hypertension, angina, and arrhythmias. It works by inhibiting the influx of calcium ions into cardiac and smooth muscle cells, which relaxes blood vessels, reduces heart rate, and decreases the force of heart contractions. This lowers blood pressure and improves blood flow, making it effective in managing cardiovascular issues.

Effect on fertility biomarkers

Verapamil may occasionally lead to hyperprolactinemia (elevated prolactin levels) by interfering with dopamine, which normally inhibits prolactin production. Elevated prolactin can disrupt the menstrual cycle and ovulation by suppressing key reproductive hormones, potentially mimicking the effects of a prolactinoma (a prolactin-secreting tumor) and affecting fertility. One case reported a 42-year-old woman with verapamil-induced hyperprolactinemia. Her symptoms resembled prolactinoma, but after stopping verapamil and taking bromocriptine to lower prolactin levels, her condition returned to normal .

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References:

Krysiak R, Okopieh B, Herman ZS. Hiperprolaktynemia spowodowana przez werapamil. Opis przypadku [Verapamil-induced hyperprolactinemia--a case report]. Pol Arch Med Wewn. 2005 Feb;113(2):155-8. Polish. PMID: 16209236.

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.