Active ingredient: Thioridazine hydrochloride

Brand Name: Mellaril, Melleril

Drug class: Antipsychotics

Mechanism of Action:

Thioridazine hydrochloride is an antipsychotic that blocks dopamine (D2) receptors, helping to manage symptoms of schizophrenia.

Effect on fertility biomarkers

Dopamine-blocking effect can lead to hyperprolactinemia, where prolactin levels are elevated. This condition may disrupt menstrual cycles and ovulation, negatively affecting fertility. Additionally, thioridazine can reduce cervical mucus production, making it thicker and possibly affecting sperm movement. It also influences the body’s temperature regulation, which may lead to issues like hypothermia (decreased body temperature).

First
Second
Third
…

Ovulation, Temperature, Menstrual cycle lenght

View the chart

References:

Maas, D. L., Hunt, S., Mark, L., & Drobny, E. C. (2001). Reversible thioridazine-induced magnetic resonance imaging-documented pituitary enlargement associated with hyperprolactinemia. The American Journal of Medicine, 111(1), 78-80. https://doi.org/10.1016/S0002-9343(01)00749-7

Comments

If you have used this medication and monitored fertility biomarkers, please share your experience.

Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.