Tetracyclines are a class of antibiotics that work by inhibiting bacterial protein synthesis. They bind to the 30S ribosomal subunit, preventing the attachment of aminoacyl-tRNA to the ribosome. This blocks the addition of new amino acids to the growing polypeptide chain, effectively halting protein production and bacterial growth.
Tetracyclines are used to treat a variety of infections, including respiratory tract infections, acne, urinary tract infections, and certain sexually transmitted infections. They are also effective against a range of bacteria, including both Gram-positive and Gram-negative species, as well as some atypical pathogens like Chlamydia and Mycoplasma. Despite their effectiveness, tetracyclines are not recommended for use in young children or pregnant women due to potential effects on bone and teeth development.
