Active ingredient: Sulfonamides

Brand Name: Bactrim. Bactrim DS. Cotrim.

Drug class: Antibiotics

Mechanism of Action:

Sulfonamides are antibiotics that inhibit bacterial synthesis of folic acid, essential for DNA and RNA production. They work by blocking the enzyme dihydropteroate synthase, which prevents the conversion of para-aminobenzoic acid (PABA) into folate. Sulfonamides are commonly used to treat urinary tract infections, respiratory infections, certain gastrointestinal infections, and conditions like toxoplasmosis.

Effect on fertility biomarkers

Some studies suggest that antibiotics, including Sulfonamides, can affect cervical mucus production and may cause secondary yeast infections. These yeast infections can, in turn, make chart reading difficult. Regarding use in women planning pregnancy, sulfonamides are generally approached with caution. While some can be used if necessary, they may pose risks, particularly in the later stages of pregnancy, potentially leading to issues like jaundice in newborns. It’s important for women planning pregnancy to consult their healthcare provider for personalized advice.

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References:

Wilton L, Kollarova M, Heeley E, Shakir S. Relative risk of vaginal candidiasis after use of antibiotics compared with antidepressants in women: postmarketing surveillance data in England. Drug Saf. 2003;26(8):589-97. doi: 10.2165/00002018-200326080-00005. PMID: 12825971. Zhanel GG, Siemens S, Slayter K, Mandell L. Antibiotic and oral contraceptive drug interactions: Is there a need for concern? Can J Infect Dis. 1999 Nov;10(6):429-33. doi: 10.1155/1999/539376. PMID: 22346401; PMCID: PMC3250726.

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.