Active ingredient: Progesterone (P4)

Brand Name: Prometrium, Utrogestan, Endometrin and others

Drug class: Progestins

Mechanism of Action:

Vaginal progesterone is commonly used to support pregnancy, especially in women with a history of miscarriage, luteal phase defects, or undergoing assisted reproductive technologies (ART). It works by preparing the uterine lining (endometrium) for implantation and maintaining early pregnancy by promoting an environment conducive to embryo development.

Effect on fertility biomarkers

Vaginal progesterone can alter cervical mucus, often making it sticky, yellow, or white, and opaque. This thicker mucus can act as a barrier to sperm, which might complicate conception if used outside specific medical indications. Additionally, it may cause vaginal irritation, discharge, or spotting, which can interfere with the observation of natural fertility signs based on mucus changes.

First
Second
Third
…

Ovulation, Mucus, Temperature

View the chart

References:

Bulletti C, Bulletti FM, Sciorio R, Guido M. Progesterone: The Key Factor of the Beginning of Life. Int J Mol Sci. 2022 Nov 16;23(22):14138. doi: 10.3390/ijms232214138. PMID: 36430614; PMCID: PMC9692968.

Comments

If you have used this medication and monitored fertility biomarkers, please share your experience.

Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.