Active ingredient: Prochlorperazine maleate

Brand Name: Compazine, Stemetil

Drug class: Antipsychotics

Mechanism of Action:

Prochlorperazine maleate is a dopamine (D2) receptor antagonist used to treat nausea, vomiting, and psychosis. By blocking dopamine receptors in the brain, it helps control these symptoms. However, like other dopamine blockers, it can lead to increased prolactin levels (hyperprolactinemia).

Effect on fertility biomarkers

Like other dopamine blockers, it can lead to increased prolactin levels (hyperprolactinemia), potentially disrupting menstrual cycles and inhibiting ovulation, which may affect fertility. Additionally, prochlorperazine can influence body temperature regulation due to its effects on the central nervous system, occasionally leading to issues such as hypothermia or hyperthermia.

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Ovulation, Temperature, Menstrual cycle lenght

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References:

Musselman ME, Browning LA, Parker D Jr, Saely S. Neuroleptic malignant syndrome associated with the use of prochlorperazine in a patient with a recent history of antipsychotic-induced neuroleptic malignant syndrome. Ann Pharmacother. 2011 Nov;45(11):e61. doi: 10.1345/aph.1Q325. Epub 2011 Oct 4. PMID: 21972252. Din L, Preuss CV. Prochlorperazine. [Updated 2023 Aug 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537083/

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.