Active ingredient: Prednisolon

Brand Name: Prednisone

Drug class: Glucocorticoid

Mechanism of Action:

Prednisolone is a synthetic corticosteroid used to reduce inflammation and suppress the immune response in various medical conditions. It works by binding to glucocorticoid receptors in cells, leading to anti-inflammatory and immunosuppressive effects. Prednisolone can also inhibit the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland, which are crucial for regulating the menstrual cycle and ovulation.

Its applications include treating inflammatory and autoimmune disorders such as asthma, arthritis, and lupus, as well as managing hormonal imbalances.

Effect on fertility biomarkers

Prednisolone can negatively affect fertility and ovulation. By preventing the release of FSH and LH, it can disrupt the normal ovulatory cycle, leading to irregular or absent ovulation and potentially impairing fertility. This can result in altered hormone levels and disrupted reproductive signaling, making conception more difficult

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References:

Janssen NM, Genta MS. The Effects of Immunosuppressive and Anti-inflammatory Medications on Fertility, Pregnancy, and Lactation. Arch Intern Med. 2000;160(5):610–619. doi:10-1001/pubs.Arch Intern Med.-ISSN-0003-9926-160-5-ira90005

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.