Active ingredient: Pipamperone

Brand Name: Dipiperon, Dipiperal, Piperonil

Drug class: Antipsychotics

Mechanism of Action:

Pipamperone is an antipsychotic that primarily acts as a dopamine (D2) receptor antagonist.

Effect on fertility biomarkers

Dopamine-blocking effect can lead to increased prolactin levels, resulting in hyperprolactinemia, which may disrupt the menstrual cycle and inhibit ovulation, adversely affecting fertility. Additionally, the elevated prolactin levels associated with pipamperone can lead to symptoms such as galactorrhea and amenorrhea in women. Hypothermia is a rare adverse effect of Pipamperone

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Ovulation, Temperature, Menstrual cycle lenght

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References:

Eikenboom HC, Janssens AR, Rosekrans PC, Molendijk W. Hypothermie bij gebruik van pipamperon [Hypothermia during use of pipamperone]. Ned Tijdschr Geneeskd. 1997 Feb 8;141(6):301-3. Dutch. PMID: 9148168. Glocker C, Grohmann R, Engel R, Seifert J, Bleich S, Stübner S, Toto S, Schüle C. Galactorrhea during antipsychotic treatment: results from AMSP, a drug surveillance program, between 1993 and 2015. Eur Arch Psychiatry Clin Neurosci. 2021 Dec;271(8):1425-1435. doi: 10.1007/s00406-021-01241-3. Epub 2021 Mar 25. PMID: 33768297; PMCID: PMC8563638.

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.