Active ingredient: Phenelzine

Brand Name: Nardil

Mechanism of Action:

Monoamine oxidase (MAO) inhibitors work by blocking the enzyme monoamine oxidase, which breaks down neurotransmitters like serotonin, dopamine, and norepinephrine in the brain. By inhibiting this enzyme, MAO inhibitors increase the levels of these neurotransmitters, helping to improve mood and alleviate symptoms of depression and anxiety. MAO inhibitors are primarily used to treat depression, particularly when other antidepressants are ineffective. However, they require dietary restrictions to avoid interactions with certain foods and medications, as they can lead to severe side effects like high blood pressure

Effect on fertility biomarkers

MAO inhibitors are generally not recommended for women planning pregnancy due to potential risks to both the mother and the fetus. These medications can interfere with hormonal balance, potentially affecting the menstrual cycle by causing irregular periods or altering ovulation, which may make it harder to conceive. Additionally, MAO inhibitors can cause sexual side effects in women, such as vaginal dryness, decreased genital sensations, reduced libido, and difficulty achieving orgasm. Vaginal dryness, in particular, may lead to reduced cervical mucus. For women trying to conceive, it is generally advised to discuss alternative treatments for depression with a healthcare provider

First
Second
Third
…

Ovulation, Mucus

View the chart

References:

Costa, B.; Vale, N. Advances in Psychotropic Treatment for Pregnant Women: Efficacy, Adverse Outcomes, and Therapeutic Monitoring. J. Clin. Med. 2024, 13, 4398. https://doi.org/10.3390/jcm13154400

Comments

If you have used this medication and monitored fertility biomarkers, please share your experience.

Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.