Active ingredient: Metoclopramide hydrochloride

Brand Name: Metoclopramide, Reglan

Drug class: Antiemetic Agents; Prokinetic Agents

Mechanism of Action:

Metoclopramide hydrochloride is a dopamine receptor antagonist primarily used to treat nausea, vomiting, and gastrointestinal conditions like gastroparesis and reflux.

Mechanism of Action:
Metoclopramide works by blocking dopamine receptors in the brain, particularly in the chemoreceptor trigger zone (which helps control vomiting). It also enhances the response of the gastrointestinal tract to acetylcholine, increasing gut motility and speeding up stomach emptying.

Effect on fertility biomarkers

Metoclopramide may affect the body’s ability to regulate temperature due to its action on dopamine receptors. This can result in hyperthermia (increased body temperature) or, more rarely, hypothermia (lowered body temperature), as part of extrapyramidal side effects, especially with high doses or prolonged use.

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References:

Yaman A, Kendirli T, Ödek Ç, Yıldız C, Beğde F, Erkol H, İnce E. Neuroleptic malignant syndrome associated with metoclopramide in a child. Turk J Pediatr. 2014 Sep-Oct;56(5):535-7. PMID: 26022591.

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.