Active ingredient: Isotretinoin

It does not directly impair fertility but may temporarily affect ovarian function, cause menstrual irregularities, and influence hormone levels, including AMH, estradiol, progesterone, and testosterone. It can also impact lipid metabolism, increase triglycerides, and alter endothelial function, which may indirectly affect reproductive health. Isotretinoin is highly teratogenic, leading to severe birth defects such as craniofacial abnormalities, cardiac malformations, and central nervous system defects, with an increased risk of miscarriage and stillbirth. Women planning pregnancy should stop taking it at least one month prior, use reliable contraception during treatment, avoid blood donation, and monitor hormonal recovery.