Active ingredient: Griseofulvin

Brand Name: Grifulvin V, Gris-PEG

Drug class: Antifungal medications

Mechanism of Action:

Griseofulvin is an antifungal medication primarily used to treat fungal infections of the skin, hair, and nails, such as ringworm and athlete’s foot. It works by binding to tubulin, inhibiting microtubule function and disrupting fungal cell division, preventing the fungus from multiplying.

Effect on fertility biomarkers

griseofulvin is a moderate inducer of cytochrome P450 enzymes in the liver. This induction can increase the metabolism of estrogen and progesterone, similar to rifampicin, potentially reducing the effectiveness of hormonal contraceptives. As a result, women using oral contraceptives while on griseofulvin may experience reduced hormone levels, increasing the risk of unintended pregnancy.

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Ovulation, Menstrual cycle length

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References:

Olson JM, Troxell T. Griseofulvin. [Updated 2023 Jul 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: Olson JM, Troxell T. Griseofulvin. [Updated 2023 Jul 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537323/ Knasmüller S, Parzefall W, Helma C, Kassie F, Ecker S, Schulte-Hermann R. Toxic effects of griseofulvin: disease models, mechanisms, and risk assessment. Crit Rev Toxicol. 1997 Sep;27(5):495-537. doi: 10.3109/10408449709078444. Erratum in: Crit Rev Toxicol 1998 Jan;28(1):102. PMID: 9347226.

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.