Active ingredient: Furosemide

Brand Name: Lasix, Furoscix

Drug class: Diuretics

Mechanism of Action:

Furosemide is a loop diuretic that works by inhibiting the reabsorption of sodium and chloride in the kidneys’ loop of Henle. This increases urine output and reduces fluid retention in the body, commonly used to treat conditions like edema (due to heart failure or kidney disease) and hypertension.

Effect on fertility biomarkers

Due to its diuretic effect, furosemide can lead to dehydration by removing excess fluids. This dehydration may reduce the production of cervical mucus, as the body’s overall fluid levels decrease, potentially affecting fertility by limiting the quality and amount of cervical secretions necessary for sperm mobility.

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Mucus

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References:

IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Pharmaceutical Drugs. Lyon (FR): International Agency for Research on Cancer; 1990. (IARC Monographs on the Evaluation of the Carcinogenic Risks to Humans, No. 50.) Furosemide (Frusemide) Available from: https://www.ncbi.nlm.nih.gov/books/NBK526234/

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.