Active ingredient: Estradiol

Brand Name: Alora, Climara, Divigel, Estrace and others

Drug class: Estrogens

Mechanism of Action:

Estradiol-containing medications mimic the hormone estradiol, a key form of estrogen, which regulates reproductive functions in women. These drugs work by binding to estrogen receptors, promoting the development and maintenance of the female reproductive system.

Effect on fertility biomarkers

Estradiol typically promotes the production of cervical mucus with fertile characteristics, such as being clear, slippery, and stretchy, which facilitates sperm movement. However, in some cases, estradiol-containing medications may also have a cholinergic action, potentially leading to dryness, either locally (vaginal) or systemically (throughout the body).

First
Second
Third
…

Ovulation, Mucus

View the chart

References:

Kokia E, Bider D, Lunenfeld B, Blankstein J, Mashiach S, Ben-Rafael Z. Addition of exogenous estrogens to improve cervical mucus following clomiphene citrate medication. Patient selection. Acta Obstet Gynecol Scand. 1990;69(2):139-42. doi: 10.3109/00016349009006159. PMID: 2386017.

Comments

If you have used this medication and monitored fertility biomarkers, please share your experience.

Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.