Active ingredient: Duloxetine

Brand Name: Cymbalta, Irenka

Drug class: Antidepressant, Serotonin-norepinephrine reuptake inhibitors (SNRIs)

Mechanism of Action:

Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI). It increases the levels of serotonin and norepinephrine in the brain by blocking their reuptake. These neurotransmitters play a key role in regulating mood and pain perception. Duloxetine is primarily used to treat depression, anxiety, and chronic pain conditions like fibromyalgia and diabetic neuropathy.

Effect on fertility biomarkers

Duloxetine may influence fertility by increasing allopregnanolone levels. Research in rodents suggests that an antidepressant-induced rise in allopregnanolone could dysregulate the hypothalamic-pituitary-ovarian (HPO) axis. Allopregnanolone increases GABA activity, which suppresses GnRH release, leading to reduced levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This can impair ovulation. In humans, allopregnanolone has been shown to decrease LH and FSH levels, potentially reducing ovulation rates and contributing to infertility by disrupting the normal hormonal rhythms required for ovulation.

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.