Active ingredient: Diphenhydramine, Dimenhydrinat

Brand Name: Dramamine, Vomex A, Benadryl

Drug class: Antihystamines

Mechanism of Action:

Diphenhydramine is an antihistamine that blocks H1 receptors to reduce allergic symptoms and has anticholinergic effects, leading to sedation. It can cause thickened bronchial secretions and dry mucous membranes, including the mouth, nose, and throat. This drying effect extends to cervical mucus, reducing its production and potentially hindering sperm movement.

Effect on fertility biomarkers

Side effects include early menses, urinary retention, dry sweat glands, and elevated body temperature, all of which can influence bodily functions and the reproductive environment.

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View the chart

References:

Sicari V, Zabbo CP. Diphenhydramine. [Updated 2023 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK526010/

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.