Active ingredient: Desvenlafaxine

Brand Name: Khedezla, Pristiq

Drug class: Antidepressant, Serotonin-norepinephrine reuptake inhibitors (SNRIs)

Mechanism of Action:

Desvenlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI). It increases serotonin and norepinephrine levels by blocking their reuptake in the brain, helping to regulate mood and relieve symptoms of depression and anxiety. It is primarily used to treat major depressive disorder (MDD).

Effect on fertility biomarkers

Desvenlafaxine may impact fertility and ovulation by influencing hormone regulation. Like other SNRIs, it can increase allopregnanolone levels, a neurosteroid that modulates GABA activity. Research suggests that allopregnanolone can suppress GnRH release, which reduces levels of LH and FSH, crucial for ovulation. This suppression may dysregulate the hypothalamic-pituitary-ovarian (HPO) axis, potentially leading to fewer ovulatory cycles and reduced fertility.

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.