Active ingredient: Cyproheptadune

Brand Name: Periactin

Drug class: Antihystamines

Mechanism of Action:

Cyproheptadine is an antihistamine and antiserotonergic agent that blocks H1 histamine receptors and serotonin receptors, reducing allergic symptoms such as itching, swelling, and hives. It also has anticholinergic properties, contributing to its sedative effects.

Effect on fertility biomarkers

Side effects include dry mouth and drying of nasal mucosae, which can extend to cervical mucus, potentially reducing its production and altering its consistency. Additionally, cyproheptadine may cause hyperthermia (elevated body temperature), which could influence overall temperature regulation

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References:

Bertrand V, Massy N, Vegas N, Gras V, Chalouhi C, Tavolacci MP, Abadie V. Safety of Cyproheptadine, an Orexigenic Drug. Analysis of the French National Pharmacovigilance Data-Base and Systematic Review. Front Pediatr. 2021 Sep 29;9:712413. doi: 10.3389/fped.2021.712413. PMID: 34676184; PMCID: PMC8525494.

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.