Active ingredient: Cyclophosphamide

Brand Name: Lyophilized Cytoxan, Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cycloblastin

Drug class: Antitumor drugs

Mechanism of Action:

Cyclophosphamide is a chemotherapy drug and alkylating agent that works by adding an alkyl group to DNA, causing DNA cross-linking and damage. This prevents cancer cells from dividing and growing, leading to cell death, especially in rapidly dividing cells.

Effect on fertility biomarkers

Effect on ovulation and fertility: Cyclophosphamide can severely affect female fertility by damaging the ovaries, leading to ovarian failure or amenorrhea (loss of menstruation). It can disrupt or stop ovulation and increase the risk of infertility and premature menopause. The likelihood of fertility issues depends on the dosage, duration of treatment, and the patient’s age, with younger women sometimes experiencing recovery of ovarian function post-treatment.

First 
Second
Third

Ovulation

References:

Comments

If you have used this medication and monitored fertility biomarkers, please share your experience.

Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.