Active ingredient: Cortisone

Brand Name: Cortef

Drug class: Steroid

Mechanism of Action:

Cortisone is a glucocorticoid, a type of steroid hormone that reduces inflammation and suppresses the immune system. It works by binding to glucocorticoid receptors, influencing gene expression to decrease the production of inflammatory proteins and immune responses. Cortisone is used to treat conditions like arthritis, allergic reactions, and autoimmune diseases.

Effect on fertility biomarkers

Cortisone can affect fertility by disrupting the hypothalamic-pituitary-gonadal (HPG) axis. Long-term use or high doses may suppress the release of gonadotropin-releasing hormone (GnRH), which in turn reduces levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), hormones critical for ovulation. This suppression can lead to irregular menstrual cycles, ovulatory dysfunction, and potential fertility issues

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References:

Janssen NM, Genta MS. The Effects of Immunosuppressive and Anti-inflammatory Medications on Fertility, Pregnancy, and Lactation. Arch Intern Med. 2000;160(5):610–619. doi:10-1001/pubs.Arch Intern Med.-ISSN-0003-9926-160-5-ira90005

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.