Active ingredient: Citrus limonum

Brand Name: Lemon

Drug class: Herbal Medicinal Products

Mechanism of Action:

Citrus limonum, commonly known as lemon, is a citrus species native to the North West region of India. It has various applications, primarily due to its high vitamin C content and antioxidant properties. In traditional medicine, lemon extracts have been used for their health benefits, including digestive aid and antimicrobial effects.

Effect on fertility biomarkers

Recent research investigated the anti-fertility effects of different extracts of Citrus limonum seeds in female albino mice. The study administered petroleum ether, alcoholic, and aqueous extracts orally for seven days post-insemination. The findings revealed that the alcoholic extract exhibited a significant anti-fertility effect compared to the other extracts. Further fractionation of the alcoholic extract identified the ethyl acetate fraction (fractions 12-25) as the most effective in demonstrating anti-fertility activity. The mechanism of action of the effective extracts primarily involved anti-zygotic properties, meaning they hindered the fertilization process and prevented successful implantation of the embryo. Notably, the withdrawal of the test drug led to the complete restoration of fertility in the treated mice, indicating that the anti-fertility effect was reversible.

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References:

Kulkarni TR, Kothekar MA, Mateenuddin M. Study of anti-fertility effect of lemon seeds (Citrus limonum) in female albino mice. Indian J Physiol Pharmacol. 2005 Jul-Sep;49(3):305-12. PMID: 16440848.

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.