Active ingredient: Cimetidine

Brand Name: Tagamet

Drug class: Histamin H2-Receptor Antagonist

Mechanism of Action:

Cimetidine is a histamine H2 receptor antagonist primarily used to reduce stomach acid production and treat conditions like gastric ulcers and acid reflux. It works by blocking the H2 receptors in the stomach lining, which decreases the release of stomach acid.

Effect on fertility biomarkers

Cimetidine, stimulates prolactin (PRL) secretion. The release of PRL after a bolus injection of the compound is more pronounced during the luteal than during the follicular phase of the menstrual cycle. Luteal progesterone was significantly diminished in the menstrual cycles when cimetidine was given.

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Ovulation, Menstrual cycle length

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References:

Jaiswal K, Krishna A. Effects of cimetidine, H2 receptor antagonist, on follicular and luteal development in the mice. Biomed Environ Sci. 1994 Jun;7(2):154-68. PMID: 7946012. Singh, Oinam Joychandra; Singh, Thokchom Imoba; Valte, Varkung. Cimetidine-induced Hyperprolactinemia. Journal of Medical Society 27(3):p 165-168, Sep–Dec 2013. | DOI: 10.4103/0972-4958.127383

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.