Active ingredient: Chlorpromazine hydrochloride

Brand Name: Thorazine

Drug class: Antipsychotics

Mechanism of Action:

Thorazine (chlorpromazine) is an antipsychotic that works by blocking dopamine (D2) receptors in the brain, helping to control psychosis and other mental health conditions. Like other dopamine blockers, it can elevate prolactin levels (hyperprolactinemia), leading to menstrual irregularities and inhibiting ovulation.

Effect on fertility biomarkers

Increased prolactin can disrupt the normal hormonal balance required for ovulation, potentially reducing fertility in women. Additionally, it may cause other reproductive issues like amenorrhea (absence of menstruation) and decreased libido due to hormone imbalances.

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Ovulation, Temperature

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References:

Zamani Z, Zare S, Sadrkhanlou R, Ahmadi A, Movahed E. The Effects of Chlorpromazine on Reproductive System and Function in Female Rats. Int J Fertil Steril. 2015 Oct-Dec;9(3):371-9. doi: 10.22074/ijfs.2015.4553. Epub 2015 Oct 31. PMID: 26644861; PMCID: PMC4671389.

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.