Active ingredient: Celecoxib

Brand Name: Celebrex, Onsenal, Elyxyb

Drug class: Non-steroidal anti-inflammatory drug (NSAID)

Mechanism of Action:

Celecoxib is a selective COX-2 inhibitor that reduces inflammation and pain by blocking the cyclooxygenase-2 enzyme, which is responsible for the formation of prostaglandins involved in inflammatory processes. It is primarily used to treat conditions like osteoarthritis, rheumatoid arthritis, and acute pain.

Effect on fertility biomarkers

While celecoxib is generally considered safe for use, there is some concern regarding its potential impact on fertility and ovulation. COX-2 plays a role in the ovulatory process and the regulation of reproductive hormones. Some studies suggest that prolonged use of COX-2 inhibitors may disrupt normal ovulatory function and impair fertility in both males and females. However, the evidence is not conclusive, and more research is needed to fully understand the implications.

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References:

Edelman AB, Jensen JT, Doom C, Hennebold JD. Impact of the prostaglandin synthase-2 inhibitor celecoxib on ovulation and luteal events in women. Contraception. 2013 Mar;87(3):352-7. doi: 10.1016/j.contraception.2012.07.004. Epub 2012 Aug 16. PMID: 22902348; PMCID: PMC4040982.

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.