Active ingredient: Cannabis sativa

Brand Name: Marijuana

Drug class: Recreational drug

Mechanism of Action:

Medical cannabis contains cannabinoids, such as THC (tetrahydrocannabinol) and CBD (cannabidiol), which interact with the body’s endocannabinoid system (ECS). Cannabinoids bind to CB1 and CB2 receptors in the brain and throughout the body, regulating various physiological processes, including pain, mood, and inflammation. THC has psychoactive effects, while CBD is non-psychoactive and primarily offers anti-inflammatory and pain-relief benefits.
Medical cannabis is used to manage chronic pain, anxiety, epilepsy, multiple sclerosis, and conditions like chemotherapy-induced nausea. It is also used for its muscle-relaxing, anti-inflammatory, and analgesic properties.

Effect on fertility biomarkers

Cannabis can negatively impact female fertility. THC may disrupt the hypothalamic-pituitary-gonadal (HPG) axis, reducing the release of luteinizing hormone (LH) and leading to ovulatory dysfunction. It may also alter the endocannabinoid system’s role in regulating ovulation, implantation, and early pregnancy. Additionally, cannabis use can affect the quality of cervical mucus, potentially impairing sperm movement, thus reducing the chances of conception.

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References:

Fonseca BM, Rebelo I. Cannabis and Cannabinoids in Reproduction and Fertility: Where We Stand. Reprod Sci. 2022 Sep;29(9):2429-2439. doi: 10.1007/s43032-021-00588-1. Epub 2021 May 10. PMID: 33970442.

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.