Active ingredient: Busulfan

Brand Name: Myleran, Busilvex

Drug class: Antitumor drugs

Mechanism of Action:

Busulfan is a chemotherapy drug classified as an alkylating agent. It works by attaching an alkyl group to DNA, leading to DNA cross-linking, which prevents cell division and causes cell death, particularly in rapidly dividing cells like cancer cells or bone marrow cells.

Effect on fertility biomarkers

Busulfan can have significant effects on female fertility. It can damage the ovaries, leading to ovarian insufficiency or amenorrhea (absence of menstruation), which can impair or halt ovulation. This increases the risk of infertility and premature menopause. The extent of its impact depends on dosage, duration of treatment, and the patient’s age. In some cases, the effects on fertility may be permanent.

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References:

Shalev O, Rahav G, Milwidsky A. Reversible busulfan-induced ovarian failure. Eur J Obstet Gynecol Reprod Biol. 1987 Nov;26(3):239-42. doi: 10.1016/0028-2243(87)90074-8. PMID: 2828130. Teinturier, C., Hartmann, O., Valteau-Couanet, D. et al. Ovarian function after autologous bone marrow transplantation in childhood: high-dose busulfan is a major cause of ovarian failure. Bone Marrow Transplant 22, 989–994 (1998). https://doi.org/10.1038/sj.bmt.1701483

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.