Active ingredient: Buserelin

Brand Name: Zerelin

Drug class: Antiandrogen

Mechanism of Action:

Buserelin is a synthetic analog of gonadotropin-releasing hormone (GnRH) used to manage hormone-dependent conditions such as endometriosis, uterine fibroids, and in IVF protocols.

Mechanism of Action:
Buserelin functions as a GnRH agonist, initially triggering the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. However, with continued use, it causes desensitization of GnRH receptors, leading to a decrease in LH and FSH production. This results in the suppression of ovarian function and a reduction in estrogen levels.

Effect on fertility biomarkers

By inhibiting LH and FSH release, Buserelin temporarily prevents ovulation, halting the release of eggs from the ovaries. The decrease in estrogen levels causes cervical mucus to become thicker and less abundant, making it more difficult for sperm to pass through the cervix.

First
Second
Third
…

Ovulation, Mucus, Temperature

View the chart

References:

Bancroft J, Boyle H, Warner P, Fraser HM. The use of an LHRH agonist, buserelin, in the long-term management of premenstrual syndromes. Clin Endocrinol (Oxf). 1987 Aug;27(2):171-82. doi: 10.1111/j.1365-2265.1987.tb01142.x. PMID: 3117452.

Comments

If you have used this medication and monitored fertility biomarkers, please share your experience.

Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.