Active ingredient: Bupropion hydrochloride

Studies in animals (rats) have not shown infertility with bupropion use. There are no specific studies on fertility in women, but two case reports linked bupropion to irregular menstrual cycles without mentioning fertility problems. There is no strong evidence that bupropion makes it more difficult to conceive. One study reported a higher rate of miscarriage in pregnant women taking bupropion compared to those not taking it, but the miscarriage rate remained within the background rate for the general population. Regarding birth defects, one study suggested a weak association between first-trimester bupropion use and heart defects, but the study design does not allow for definitive conclusions. The manufacturer’s pregnancy registry has not found an increased risk of birth defects. Women planning pregnancy should consult their healthcare provider to weigh the risks and benefits of bupropion use.