Active ingredient: Amitriptyline

Brand Name: Elavil, Vanatrip

Drug class: Antidepresant, Tricyclic antidepressants (TCAs)

Mechanism of Action:

Amitriptyline is a tricyclic antidepressant that works by inhibiting the reuptake of neurotransmitters like serotonin and norepinephrine, increasing their levels in the brain to improve mood and alleviate depression and anxiety.

It is primarily used to treat depression, chronic pain, migraines, and some anxiety disorders.

Effect on fertility biomarkers

Regarding fertility, amitriptyline may affect hormone levels and menstrual cycles, potentially leading to irregular ovulation. It can also reduce cervical mucus, making it harder for sperm to reach the egg. Additionally, sexual dysfunction is a common side effect, which can include decreased libido, difficulty with arousal, and reduced sexual satisfaction

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Ovulation, Mucus, Temperature

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References:

Casilla-Lennon MM, Meltzer-Brody S, Steiner AZ. The effect of antidepressants on fertility. Am J Obstet Gynecol. 2016 Sep;215(3):314.e1-5. doi: 10.1016/j.ajog.2016.01.170. Epub 2016 Jan 28. PMID: 26827878; PMCID: PMC4965341. https://pmc.ncbi.nlm.nih.gov/articles/PMC4965341/ Uzunova V, Wrynn AS, Kinnunen A, Ceci M, Kohler C and Uzunov DP (2004). Chronic antidepressants reverse cerebrocortical allopregnanolone decline in the olfactory bulbectomized rat. Eur J Pharmacol. 486(1): 31–34 https://pubmed.ncbi.nlm.nih.gov/14751405/ Timby E, Hedström H, Bäckström T, Sundström-Poromaa I, Nyberg S and Bixo M (2011). Allopregnanolone, a GABAA receptor agonist, decreases gonadotropin levels in women. A preliminary study. Gynecol Endocrinol Off J Int Soc Gynecol Endocrinol. 27(12): 1087–1093. DOI: 10.3109/09513590.2010.540603 https://pubmed.ncbi.nlm.nih.gov/21190418/

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.