Aminoglycosides are a class of antibiotics that inhibit bacterial protein synthesis by binding to the 30S ribosomal subunit. This binding causes misreading of mRNA, leading to the production of defective proteins and ultimately resulting in bacterial cell death.
They are primarily used to treat serious infections caused by Gram-negative bacteria, such as Pseudomonas aeruginosa and Escherichia coli. Common applications include severe infections like sepsis, pneumonia, and intra-abdominal infections, often in combination with other antibiotics.
