Active ingredient: Actinomycin D

Brand Name: Cosmegen

Drug class: Antitumor drugs

Mechanism of Action:

Actinomycin D is an antibiotic and chemotherapeutic agent that inhibits DNA transcription by binding to DNA’s guanine base, preventing RNA polymerase from synthesizing messenger RNA. This action disrupts protein synthesis in rapidly dividing cells, including cancer cells.

Effect on fertility biomarkers

Actinomycin D can adversely affect female fertility by damaging ovarian function, potentially leading to ovarian failure or amenorrhea. This disruption can impair or halt ovulation, increasing the risk of infertility, especially with higher doses or prolonged treatment.

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References:

Xue W, Cang W, Zhao J, Feng F, Wan X, Ren T, Qiu L, Yang J, Xiang Y. Effect of actinomycin D on ovarian reserve in low-risk gestational trophoblastic neoplasia. Int J Gynecol Cancer. 2023 Aug 7;33(8):1222-1226. doi: 10.1136/ijgc-2023-004292. PMID: 37290904; PMCID: PMC10423527.

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.