Active ingredient: Acetazolamide

Brand Name: Diamox

Drug class: Diuretics

Mechanism of Action:

Acetazolamide is a carbonic anhydrase inhibitor that reduces the reabsorption of bicarbonate in the kidneys, leading to increased urine output and a more acidic urine. It is primarily used to treat glaucoma, altitude sickness, epilepsy, and sometimes edema.

Effect on fertility biomarkers

Acetazolamide decreased progesterone levels in serum and uterine fundus and increased corticosteroid levels in the adrenal glands. Lower progesterone and altered hormonal balance may contribute to a decrease in libido.

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References:

Kamp-Jensen, C., Donslund, L. N., Styrishave, B., Højland Jensen, R., & Westgate, C. S. J. (2024). Exposure to topiramate and acetazolamide causes endocrine disrupting effects in female rats during estrus. Toxicology and Applied Pharmacology, 486, 116919. https://doi.org/10.1016/j.taap.2024.116919

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.