Active ingredient: Acetaminophen (N-acetyl-p-aminophenol)

Brand Name: Paracetamol, Tylenol, Excedrin, Calpol, Panadol.

Drug class: Non-opioid analgesic and antipyretic agent

Mechanism of Action:

Acetaminophen, also known as paracetamol, primarily acts as an analgesic (pain reliever) and antipyretic (fever reducer). It works by inhibiting the synthesis of prostaglandins in the brain, which helps to decrease pain and reduce fever. Unlike nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen has minimal anti-inflammatory effects.

Effect on fertility biomarkers

Acetaminophen (paracetamol) is generally considered to have minimal direct impact on ovulation compared to nonsteroidal anti-inflammatory drugs (NSAIDs). However, its use can affect basal body temperature (BBT), which is a crucial parameter for tracking ovulation and fertility.

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References:

Jukic AMZ, Padiyara P, Bracken MB, McConnaughey DR, Steiner AZ. Analgesic use at ovulation and implantation and human fertility. Am J Obstet Gynecol. 2020 May;222(5):476.e1-476.e11. doi: 10.1016/j.ajog.2019.11.1251. Epub 2019 Nov 15. PMID: 31738897; PMCID: PMC7195999. https://pmc.ncbi.nlm.nih.gov/articles/PMC7195999/#:~:text=Use%20of%20non%2Daspirin%20NSAIDs,2.05%20(1.23%2C%203.41). Gerriets V, Anderson J, Patel P, et al. Acetaminophen. [Updated 2024 Jan 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482369/

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Disclaimer: The information provided may not include all possible interactions or side effects of medication. The effects on fertility biomarkers can vary and may depend on the dosage, how long the medication is used, the medical condition, or other factors. This database is for informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider or a qualified health professional if you have questions about medications, fertility, or medical conditions.